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Literatur-Übersicht
Simultaneous respiratory tract colonization by multiple strains
of nontypeable haemophilus influenzae in chronic obstructive pulmonary
disease: implications for antibiotic therapy.
Autor – Murphy TF; Sethi S;
Klingman KL; Brueggemann AB; Doern GV
Zeitschrift/Erscheinungsdatum –
J Infect Dis 1999 Aug;180(2):404-9.
STUDY OBJECTIVES:
Nontypeable Haemophilus influenzae often causes exacerbations of chronic
obstructive pulmonary disease (COPD), and these exacerbations are frequently
treated with oral antibiotics. The goals of this study were to determine
the frequency of the simultaneous presence of multiple strains of H. influenzae
in sputum and to measure the MICs of antibiotics for the isolates. In
a prospective study, adults with COPD were seen monthly. Sputum cultures
were obtained, and individual colonies were subjected to genomic DNA typing
and MIC determinations. Multiple strains of H. influenzae were present
simultaneously in the sputum of 26.3% of adults with COPD. In 64.5% of
these, MICs of >/=1 antibiotic varied by >/=4-fold among the strains.
Therefore, multiple strains of H. influenzae are frequently present simultaneously
in the sputum of adults with COPD, and the antimicrobial susceptibility
of different strains in the same sputum sometimes differs.
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