<<<   eine Seite zurück

<<<   zurück zur Literatur-Übersicht

Reappraisal of clindamycin IV monotherapy for treatment of mild-to-moderate aspiration pneumonia in elderly patients.

Autor – Kadowaki M; Demura Y; Mizuno S; Uesaka D; Ameshima S; Miyamori I; Ishizaki T

Zeitschrift/Erscheinungsdatum – Chest 2005 Apr;127(4):1276-82.

STUDY OBJECTIVES:

We compared the effects of IV administration of a half dose of ampicillin/sulbactam (SBT/ABPC), normal dose of SBT/ABPC, IV clindamycin, and IV panipenem/betamiprom (PAPM/BP) for treatment of mild-to-moderate aspiration pneumonia in elderly patients. DESIGN: Randomized prospective study. PATIENTS: One hundred adult patients with compatible signs and symptoms of aspiration pneumonia. ASSESSMENTS: Patients were assessed before, during, and after treatment regarding symptoms, as well as results of laboratory values, chest radiograph examinations, and sputum bacterial cultures. RESULTS: We found few differences between the groups regarding cure rate, duration of IV medication, and occurrence of adverse effects with the tested therapies. However, clindamycin therapy was less expensive and was associated with a lower rate of posttreatment occurrence of methicillin-resistant Staphylococcus aureus. CONCLUSIONS: Clindamycin therapy for mild-to-moderate aspiration pneumonia is clinically effective, and provides economic advantages as compared to SBT/ABPC or PAPM/BP therapy.